Argenx Broke Its 200-Day When It Ended a Phase 3 Sjögren's Trial, and a Same-Day Celiac Win Did Not Hold It

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Article published Oct 12, 2026. Prices below use latest available snapshots.

ARGX Price Structure

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The Story Right Now (as of 2026-10-12)

Argenx ($ARGX) is cratering, and the break dates to October 8, when the stock fell 11.83% on 8.92 times average volume after the company ended its Phase 3 trial of VYVGART in Sjögren's disease. It has closed below its 200-day average on all three sessions from October 8 through October 12, at the end of a slide from early-September highs near $1,073 (derived from the stock's distance to its 52-week high). The long trend is under test: the stock is up 51.35% over two years and its 50-day average still sits above the 200-day, but the one-year gain has shrunk to 1.59%, 15.76 points behind the S&P 500. The June 29 dive's stop, set at about $830, gave way at the October 8 close, and its deeper line, about $815, at the October 12 close. The sales engine did not change that day. VYVGART product net sales rose 90% to $4.15 billion in 2025 (IFRS, US dollars, 20-F), and the failed trial was a bet on a new label. The call is to stand aside until a base reclaims the 200-day after the October 22 report: entry $852–$870, stop $805, first target $928.

Data as of 2026-10-12 close: ARGX $812.30, RSI 24.6, down trend, −13.4% vs SMA20, −15.0% vs SMA50, −4.6% vs SMA200, 1D −1.54%, 7D −11.02%, 30D −17.48%, 3M −7.30%, 1Y +1.59%, 2Y +51.35%, 1Y vs S&P 500 −15.76 points, −24.28% from the 52-week high, relative volume 0.59× (price summaries, Polygon close).

What happened on October 8. Argenx furnished two press releases on a 6-K that day; the exhibit text is not on disk. Zacks (October 9) and Endpoints News report that argenx discontinued UNITY, its Phase 3 trial of VYVGART HYTRULO, the subcutaneous form of efgartigimod, in Sjögren's disease. The 20-F described UNITY as a registrational, 480-patient trial with topline results expected in the second half of 2027, so it stopped about a year early. A stockanalysis.com summary of a Morgan Stanley note gives the reason as a futility finding; the reason is not in the filing. The same day, argenx reported that FB102, an anti-CD122 antibody, met the primary endpoint of a Phase 2 celiac study (p = 0.0176) and will advance to Phase 3 (company release). FB102 came with Forte Biosciences, bought for about $2.2 billion in cash in a deal that closed August 27. The win came from a newly bought asset; the loss came from the core drug's expansion plan.

Why the market sold the core drug. The 20-F says Sjögren's has no FDA-approved treatment, which made UNITY one of the larger new labels on argenx's schedule. The company's own risk factors warn that a negative result in one indication "could negatively impact the perception of the efficacy and safety of such product or product candidate in a different indication." The selling was company-specific: the 37 biotech names covered alongside it, drawn from the iShares Biotechnology ETF, moved a median −0.7% that day with 12 rising (October 8 market brief). Morgan Stanley cut its target to $1,140 from $1,250 and kept an Overweight rating (stockanalysis.com summary).

The setup. At $812.30 the stock sits 4.6% under a 200-day of $851.80 at RSI 24.6, oversold. Just above is $824.50, the past year's most-traded price. Below are a support shelf at $790.26, the 30-day intraday low of $787.73 and $781.70, the bottom of the past year's heaviest-traded zone. The bottom → pop → flag → breakout sequence has not started. The October 22 report, scheduled before the open by the provider calendar, is the next test.

Quick Snapshot (as of 2026-10-12)

Question Answer
The call 🟡 Stand aside until a base reclaims the 200-day. Entry $852–$870 · stop $805 · first target $928 · low conviction
What is argenx? A Dutch biotech (Amsterdam head office, primary listing on Euronext Brussels, one ordinary share per Nasdaq ADS) that sells VYVGART, the first FcRn blocker: an antibody fragment that lowers the IgG antibodies behind several autoimmune diseases. Approved in generalized myasthenia gravis (gMG) and CIDP worldwide and in ITP in Japan, as an infusion, a subcutaneous injection and a prefilled syringe (20-F).
Doing well or cratering? Cratering since October 8. -4.6% vs the 200-day, 1.59% over one year, -15.76 points vs the S&P 500 over one year, 51.35% over two years, -24.28% from the 52-week high.
Why look now? October 8 brought the first outright Phase 3 failure in argenx's 2026–27 readout schedule and a break of the 200-day; both levels the June dive set ($830 and $815) have given way. The stock left the Momentum Board's list of multi-year outperformers in pullback after October 7.
What is the proof? 2025 product net sales $4.15B, +90%; operating profit $1.05B against a $21.7M loss in 2024; cash $3.49B plus $0.9B of current financial assets at December 31, 2025 (20-F, IFRS, US dollars).
What is the objection? The growth plan leans on new labels, and UNITY was one. The US supplied 85.1% of 2025 product net sales (derived) and four US customers about 78% (20-F). The filed risks name US drug-price negotiation and same-class competitors. The first-half 2026 report is not in the filings on disk.
Stock setup Under the 200-day ($851.8) at RSI 24.6, above a $790.26 shelf; the 50-day ($955.51) still sits above the 200-day. No base yet.

Action Matrix (as of 2026-10-12)

Signal Condition Level Why
🟡 Wait Tonight: under the 200-day, oversold, no base, before the October 22 report Close $812.3 on 2026-10-12 Graded drawdown buys have lagged; no pop or flag has formed
🟢 Buy A settled close back above the 200-day that holds a retest, after the October 22 report $852–$870 (200-day $851.8 tonight) A reclaim restores the long trend; the stop sits 5.5%–7.5% under the zone
🟡 Wait A bounce that stalls under the 200-day, or a report-day gap that runs past $870 — No chase; buy the retest
🔴 Out A settled close below $805 $805, under every close since the trial news (lowest $812.30 on October 12) and the $807.38 shelf marked on October 8–9 The reclaim has failed; also the stop for any position opened on the buy signal. The June 29 call set its stop at about $830, which gave way at the October 8 close of $818.63; written as "below the 50-day," it had stopped meaning $830 long before, with the 50-day at $955.51 by October 12
🟠 Target First objective after a confirmed buy $928, the October 7 close at the top of the trial-news gap; then about $1,073, the 52-week high (derived) Gap fill first; trim or trail there
🔴 Thesis breaks The October 22 report shows VYVGART growth stalling or a cut outlook; a second registrational miss among the fourth-quarter readouts (EMPASSION in MMN, ADVANCE-NEXT in ITP); a label or safety action on efgartigimod — Each moves the damage from one expansion bet into the franchise

The call: 🟡 Stand aside until a base reclaims the 200-day, then buy the retest at $852–$870. Low conviction. The business record is strong and filed. The price broke on news about the core drug, the one-year return is flat and 15.76 points behind the S&P 500, and the next two catalysts, the October 22 report and the fourth-quarter readouts, can move the stock in either direction. Buying under the 200-day now is a drawdown buy: in graded calls published so far, bottom-fishing buys finished ahead of the S&P 500 once in five, while thesis-driven buys did in five of six (small samples). The June dive's business reasons, a profitable and fast-growing FcRn franchise, still hold in the filings; its chart reason, a clean uptrend with room to run, is gone. The trade is thin even after a reclaim: from the zone, the first target pays 6.7%–8.9% against 5.5%–7.5% of risk. The case for taking it rests on the second objective near the old high, which needs the report to restore confidence in growth.

What would change it. A report on October 22 that shows VYVGART growth holding and says the Sjögren's stop changes no other efgartigimod program upgrades the call on a reclaim. Positive EMPASSION or ADVANCE-NEXT results in the fourth quarter would rebuild the label-expansion case. A settled close below $805 before any reclaim deepens the break, and a 50-day average falling through the 200-day would mark the long trend broken.

Extended analysis