Biotech Scan
Biotech Scan
Data as-of 2026-07-31 close, except A which carries a 2026-07-30 bar — read that row as one session stale.
ALNY is the session's clear break: RSI 50.8 → 23.5, -24.4% over the week and -58.5% off its 52-week high — a single-name earnings-driven crash, not a sector-wide move. Everywhere else, the prior scan's five-name overbought cluster largely unwound: IQV (79.1 → 68.2), INCY (75.9 → 55.2), AMGN (72.8 → 64.9), and ABBV (70.2 → 51.9) all dropped back below the line. Only REGN pushed the other way, spiking to the cut's new high print at RSI 78.1 (+22.1% over 30 days), with DXCM close behind after an outsized single-day pop (RSI 54.6 → 68.6, +11.95% in one session). ISRG relapsed back under 40 (42.4 → 39.9), giving back last scan's recovery.
Source: biotech-scan.json. Latest bar 2026-07-31 for every name in this cut except A (2026-07-30). Prior scan: 2026-07-28-biotech-scan.
Quick Snapshot
| Signal | Reading |
|---|---|
| Overall | 🔴 Broad reset — the prior overbought cluster unwound almost in unison while ALNY crashed on its own print, the cut's new low print |
| Leaders | REGN (RSI 78.1↑, fresh spike, +22.1% 30D); DXCM (68.6, spiked on an 11.95% single-day move); TMO (68.8, held near flat) |
| Laggards | ALNY (RSI 23.5↓, -24.4% this week, "collapse" regime); LEGN (24.1↓, extended its decline further); IONS (26.3↓, -34.6% 30D) |
| Key insight | The five-name overbought cluster from the prior scan (IQV, INCY, AMGN, ABBV, TMO) unwound to just one name (REGN) — and that one got there with a fresh spike, not a holdover |
What's Going On
ALNY posted the session's clearest break. RSI fell from 50.8 to 23.5 on a -24.38% single week (change7d per biotech-scan.json), leaving the stock -58.53% off its 52-week high with the regime classifier now reading "collapse" — the cut's new lowest print, and by the week's own context a single-name earnings miss rather than a lane-wide breakdown.
The rest of the large-cap complex cooled together rather than in isolated pockets. IQV's RSI fell from 79.1 to 68.2, INCY's from 75.9 to 55.2, AMGN's from 72.8 to 64.9, and ABBV's from 70.2 to 51.9 — all four dropping back below the overbought line after crossing it three sessions ago. NVO (63.4 → 43.2), LLY (61.9 → 45.8), and COGT (63.1 → 50.7) posted comparably large single-scan drops without any regime downgrade — all three remain in an "uptrend" read, just pulled back from a stronger prior extension.
REGN and DXCM moved the opposite direction. REGN's RSI climbed from 64.7 to 78.1 — the highest print in this cut — on +16.25% over the week and +22.08% over 30 days (change7d, change30d), with relative volume at 1.44x average. DXCM spiked from 54.6 to 68.6 on an 11.95% single-day move (change1d), +21.19% over 30 days, at 2.66x average volume — both names now extended enough that a fresh entry means chasing rather than buying a pullback.
ISRG gave back its recovery. RSI fell from 42.4 back to 39.9 — under the oversold line again — after last scan flagged real tape improvement. The regime classifier still reads "collapse," the trend remains strong-down DC, and the thesis flag on file still says "intact." LEGN (24.6 → 24.1) and IONS (30.2 → 26.3) both extended their prior declines rather than stabilizing.
What Changed Since Prior Scan (2026-07-28)
- ALNY crashed. RSI 50.8 → 23.5, -24.4% over the week, -58.5% off its 52-week high — the cut's new lowest print; regime downgraded to "collapse."
- The five-name overbought cluster unwound to one. IQV 79.1 → 68.2, INCY 75.9 → 55.2, AMGN 72.8 → 64.9, ABBV 70.2 → 51.9 all dropped back below RSI 70; only REGN remains above the line.
- REGN spiked to the cut's new high. RSI 64.7 → 78.1, +22.1% over 30 days.
- DXCM spiked on an outsized single day. RSI 54.6 → 68.6, +11.95% in one session, +21.2% over 30 days.
- ISRG relapsed back under 40. RSI 42.4 → 39.9, giving back last scan's recovery out of the oversold band; regime still "collapse."
- LEGN and IONS both extended their prior declines. LEGN: 24.6 → 24.1. IONS: 30.2 → 26.3, -34.6% over 30 days.
- NVO, LLY, JNJ-adjacent large caps all cooled hard. NVO 63.4 → 43.2, LLY 61.9 → 45.8, COGT 63.1 → 50.7 — none downgraded on regime, all just pulled back.
- A's bar is one session stale (2026-07-30) — read that row as a snapshot from Thursday's close.
- Universe unchanged. Same 39 tickers as the July 28 cut — no entrants or dropouts.
How To Read The Board
RSI measures how stretched a stock is over the past 14 sessions — under 30 signals oversold, over 70 signals overbought/extended. vs SMA20 is the price gap to the 20-day average; a large negative number means a fast recent decline. vs VWAP is the premium (or discount) versus the average price paid by everyone still holding — a big positive number means most of a name's move is unrealized gain that can get sold into weakness. Trend pairs direction/strength with a cross signal: GC (golden cross, the short-term average above the long-term average) is structurally healthier than DC (death cross). A stock at a low RSI while still marked strong-down DC or in a "collapse" regime — like ALNY and ISRG here — is not a confirmed buy signal; it means the price is cheap relative to its own recent range, not that the structure has turned.
Price Table
| Stock | Price | RSI | vs SMA20 | 7D% | 30D% | 3M% | 52wkHi% | Trend | vs VWAP |
|---|---|---|---|---|---|---|---|---|---|
| ALNY | $205.52 | 23.5 ↓ | -26.4% | -24.4% | -31.9% | -30.6% | -58.5% | strong-down DC | -43.3% |
| LEGN | $18.55 | 24.1 ↓ | -20.8% | -16.5% | -37.9% | -21.4% | -52.8% | down GC | -27.8% |
| IONS | $51.77 | 26.3 ↓ | -13.4% | -8.5% | -34.6% | -31.2% | -40.3% | strong-down DC | -25.7% |
| SRPT | $14.86 | 31.4 ↓ | -13.9% | -5.2% | -18.4% | -30.9% | -41.3% | strong-down DC | -23.0% |
| NTLA | $10.68 | 32.9 | -15.9% | -0.5% | -38.1% | -19.5% | -62.2% | down GC | -21.9% |
| RARE | $24.91 | 33.8 | -16.5% | -7.4% | -23.1% | +0.6% | -37.6% | down GC | -6.5% |
| BEAM | $25.52 | 35.7 | -13.2% | +1.7% | -23.8% | -16.9% | -33.3% | down GC | -4.0% |
| EDIT | $2.58 | 38.4 | -13.9% | -0.8% | -21.3% | -11.0% | -43.1% | down GC | -9.3% |
| ISRG | $353.33 | 39.9 | -5.9% | +4.7% | -12.2% | -22.8% | -41.5% | strong-down DC | -24.0% |
| MRNA | $54.82 | 40.9 | -14.0% | +1.4% | -24.4% | +20.8% | -36.0% | weak-down GC | +38.4% |
| CRSP | $47.99 | 41.7 | -5.5% | +3.1% | -13.7% | -7.1% | -38.9% | strong-down DC | -14.3% |
| RXRX | $3.00 | 41.9 | -7.3% | +1.4% | -18.3% | -11.5% | -58.2% | strong-down DC | -34.4% |
| LABU | $227.40 | 42.1 | -15.3% | -7.4% | -19.4% | +31.0% | -31.7% | weak-down GC | +61.4% |
| NVO | $47.08 | 43.2 | -5.1% | -3.5% | -3.5% | +7.3% | -26.6% | strong-up GC | +0.5% |
| XBI | $147.01 | 43.9 | -4.9% | -2.3% | -6.1% | +12.8% | -11.3% | strong-up GC | +21.3% |
| KYMR | $103.40 | 44.7 | -7.7% | -6.5% | -9.5% | +28.1% | -20.5% | strong-up GC | +33.5% |
| BNTX | $90.58 | 45.5 | -1.5% | +1.4% | -3.6% | -7.1% | -27.0% | strong-down DC | -7.6% |
| DNA | $8.09 | 45.5 | -3.8% | +9.9% | -21.3% | -16.6% | -54.0% | strong-down DC | -18.9% |
| LLY | $1,148.84 | 45.8 | -3.0% | -4.0% | -3.6% | +19.5% | -8.1% | strong-up GC | +22.9% |
| VRTX | $477.10 | 48.4 | -2.0% | -0.1% | -4.2% | +12.5% | -10.6% | strong-up GC | +8.6% |
| GILD | $130.21 | 48.7 | -1.5% | +0.7% | +3.4% | -0.4% | -17.2% | weak-up DC | +2.8% |
| IBB | $186.41 | 48.9 | -2.2% | -0.9% | -2.0% | +11.5% | -6.4% | strong-up GC | +13.2% |
| IBBQ | $32.10 | 49.2 | -2.1% | -0.6% | -1.8% | +11.4% | -6.2% | strong-up GC | +11.4% |
| BIIB | $202.95 | 50.2 | +0.1% | +0.4% | -3.2% | +8.5% | -7.6% | strong-up GC | +17.8% |
| COGT | $38.93 | 50.7 | -1.4% | -2.1% | +1.2% | +6.3% | -11.0% | strong-up GC | +24.3% |
| ABBV | $250.94 | 51.9 | -0.9% | -3.3% | +0.7% | +22.3% | -6.2% | strong-up GC | +14.1% |
| DHR | $194.98 | 52.3 | -0.2% | +1.8% | +0.7% | +11.6% | -19.7% | weak-up DC | -2.4% |
| NKTR | $70.67 | 54.0 | +0.9% | -0.1% | +9.8% | -18.3% | -35.2% | strong-up GC | +17.0% |
| BMRN | $60.02 | 55.0 | +0.6% | +1.2% | +3.8% | +11.0% | -9.4% | strong-up GC | +6.5% |
| INCY | $119.52 | 55.2 | +1.0% | +1.6% | +5.0% | +23.3% | -9.9% | strong-up GC | +21.5% |
| PTGX | $136.64 | 57.8 | +0.8% | +0.4% | +9.2% | +38.9% | -4.6% | strong-up GC | +55.3% |
| MDT | $85.39 | 58.3 | +2.4% | +2.6% | +7.8% | +7.7% | -19.7% | weak-up DC | -3.4% |
| A* | $138.71 | 59.2 | +3.0% | -0.7% | +4.4% | +20.3% | -13.5% | strong-up GC | +7.4% |
| AMGN | $385.16 | 64.9 | +3.9% | +2.4% | +6.6% | +17.7% | -3.2% | strong-up GC | +16.8% |
| ILMN | $205.10 | 67.6 | +6.6% | +5.7% | +11.5% | +51.1% | -0.4% | strong-up GC | +54.6% |
| IQV | $235.02 | 68.2 | +10.1% | +13.0% | +15.7% | +49.0% | -6.5% | up DC | +21.8% |
| DXCM | $83.45 | 68.6 | +11.9% | +16.7% | +21.2% | +36.0% | -1.5% | strong-up GC | +22.0% |
| TMO | $574.30 | 68.8 | +5.9% | +1.1% | +11.9% | +22.5% | -10.8% | up DC | +10.5% |
| REGN | $762.63 | 78.1 ↑ | +12.8% | +16.3% | +22.1% | +8.9% | -7.1% | up DC | +13.9% |
*A carries a 2026-07-30 bar — one session stale, likely a data-refresh delay; read this row with that caveat.
Tier Analysis
Extreme Oversold (RSI < 25)
ALNY (23.5) and LEGN (24.1). ALNY is a fresh, single-name earnings crash (-24.4% this week); LEGN is an extension of a multi-scan decline. Both remain in a "collapse"/"downtrend" regime — neither has a confirmed reversal signal.
Oversold band (RSI 25-40)
IONS (26.3), SRPT (31.4), NTLA (32.9), RARE (33.8), BEAM (35.7), EDIT (38.4), ISRG (39.9). Seven names, most in "downtrend" or "collapse" regimes with no confirmed floor. ISRG is the notable relapse here — it briefly cleared this band last scan.
RSI 40+ (everyone else)
- Cooling band: MRNA, CRSP, RXRX, LABU, NVO, XBI, KYMR, BNTX, DNA, LLY. Nearly all cooled hard from a stronger prior read rather than breaking down further.
- Basing band: VRTX, GILD, IBB, IBBQ, BIIB, COGT, ABBV, DHR, NKTR, BMRN, INCY, PTGX. None extended, none broken — the cleanest zone in the cut.
- Momentum band: MDT, A, AMGN, ILMN, IQV, DXCM, TMO, REGN. Only REGN (78.1) is above the 70 overbought line this scan — down from five names last time.
Entry Zones
| Stock | Price | Zone | RSI | 30D% | Setup |
|---|---|---|---|---|---|
| GILD | $130.21 | <$127.48 (support shelf) | 48.7 | +3.4% | Cooled hard from last scan's read, clean structure |
| DHR | $194.98 | <$192.73 (support shelf) | 52.3 | +0.7% | Cooled from a stronger prior read, not extended vs VWAP |
| DXCM | $83.45 | <$73.87 (support shelf) | 68.6 | +21.2% | Spiked on an outsized single day; let the move settle before entering |
| REGN | $762.63 | Extended — no clean entry | 78.1 | +22.1% | Highest RSI in the cut, fresh spike; wait for a pullback rather than chase |
| ALNY | $205.52 | No support shelf identified | 23.5 | -31.9% | Crashed on its own print this week; "collapse" regime, no confirmed floor |
Action Matrix
| Action | Stocks | Why |
|---|---|---|
| 📈 ACCUMULATE | GILD, IBB, IBBQ | Cooled hard, basing/uptrend structure, not extended |
| 🔒 HOLD | LLY, VRTX, BIIB, COGT, ABBV, BMRN, INCY, PTGX, AMGN, ILMN, TMO | Uptrends intact after cooling from prior extension; don't chase at current levels |
| 🔍 WATCH | MRNA, LABU, NVO, XBI, KYMR, BNTX, DHR, NKTR, A | Pullback-regime names with no confirmed direction either way |
| ⚠️ AVOID / DON'T CHASE | REGN, DXCM, IQV | Freshly extended into overbought/breakout territory this scan |
| ❌ AVOID / FALLING KNIFE | ALNY, LEGN, IONS, SRPT, NTLA, RARE, BEAM, EDIT, ISRG, CRSP, RXRX, DNA, MDT | "Collapse" or "downtrend" regime — structurally the most damaged names in the cut |
What To Watch Next
- ALNY crashed on its own print this week — does it stabilize, or does the decline keep compounding?
- The prior five-name overbought cluster unwound almost entirely in one scan — does the group stay reset, or does it re-extend from here?
- REGN spiked to the cut's highest RSI (78.1) — does it give this back the way the rest of the cluster just did, or does it hold?
- ISRG relapsed back under RSI 40 after recovering last scan — does the "collapse" regime read finally get confirmed, or does it bounce again?
Sources
- Tape data (price/RSI/SMA/returns): full-scan pre-computed summaries as of the 2026-07-31 close — biotech-scan.
Related
10 eventsNo direct external sources are attached to this read.